Title: Neurodevelopmental outcome in prenatally diagnosed isolated agenesis of the corpus callosum
Authors: Chadie, A., Radi, S., Trestard, L., Charollais, A., Eurin, D., Verspyck, E., Marret, S.
Journal: Acta Paediatrica, 97, 420-424
Published: 2008
This French study looked at the outcome of 20 children who were diagnosed with isolated ACC before they were born. Children were generally younger than 6 years when assessed, but ranged between 3 and 16 years. Neurodevelopmental outcome, as defined by general intelligence, motor and cognitive abilities, was considered to be normal in 11 children (55%), which included eight with complete ACC. Five children (25%) were considered to have moderate disabilities (speech delay, comprehension difficulties, attention disorders), and four children (20%) had severe disabilities (intellectual disability, speech impairments, cerebral palsy). In three of the four severely disabled children, a follow-up MRI scan showed additional major cerebral abnormalities that were not detected in their prenatal scan.