Title: Neurodevelopmental outcome in prenatally diagnosed isolated agenesis of the corpus callosum
Authors: Folliot-Le Doussal, L., Chadie, A., Basseur-Daudruy, M., Verspyck, E., Saugier-Veber, P., Marret, S., & the Perinatal Network of Haute-Normandie
Journal: Early Human Development
Published: 2018
This French study (based in Normandy) was a long-term follow-up of 25 children who were diagnosed with isolated ACC before they were born (previously reported in Chadie et al., 2008; see below). Children were on average 8 years when assessed at follow-up, but ranged between 2 and 16 years. Neurodevelopmental outcome, as defined by general intelligence, motor and cognitive abilities, was considered to be normal in 9 children (36%), which included 6 with complete ACC. Thirteen children (52%, 8 with complete ACC) were reported to have mild disabilities, such as language disorders, attention deficit disorder and anxiety. Three children (12%, all with complete ACC) had moderate/severe disabilities (intellectual disability, speech impairments, significant delay in motor skills). One child classified as having
moderate/severe disabilities was found to have additional cerebral abnormalities in a MRI scan that were not detected in their prenatal scan.
Measures of intellectual functioning were taken from 15 children, with the majority showing intact skills (40% had an IQ score above 85, 80% had an IQ score above 70). However some discrepancies were noted with relative weaknesses in verbal comprehension, social judgement and executive functions. The rate of children with normal development was lower than in their earlier follow-up study (36% vs. 55%), with six children who had been classified as having normal development now showing mild disabilities at an older age. The authors emphasise the importance of ongoing monitoring of children with ACC and that problems may occur beyond school age.