Title: Isolated corpus callosum agenesis: A ten-year follow-up after prenatal diagnosis (How are the children without corpus callosum at 10 years of age?)
Authors: Moutard, M.-L., Kieffer, V., Feingold, J., Lewin, F., Baron, J.-M., Adamsbaum, C., Gélot, A., Isapof, A., Kieffer, F., & De Villemeur, T.B.
Journal: Prenatal Diagnosis, 32(3), 277-283
Published: 2012
This French study is a follow-up of the 17 children diagnosed with ‘apparently isolated ACC’ previously reported in the Moutard et al. (2003) study (see below). As five children were not able to return for testing, the paper reports the outcome of 12 children at 10 years of age. One child was given a late diagnosis of fetal alcohol syndrome (FAS) with ACC considered to be associated with this syndrome; his assessment results were still included in their analysis.
Most children showed good outcome with intelligence levels within the normal range (i.e., above 80) for 67% of the group (8 from 12). However, mild learning difficulties were often reported which included slowness (58%), lack of concentration/attention (33%) and emotional immaturity (42%). All children attended a mainstream school, with approximately half needing some special adaptations in the classroom to support their learning. Outcome was not related to whether the child had complete or partial ACC, was male or female, or experienced febrile seizures.
The number of children classified with borderline intelligence (i.e. below 80) was higher than the earlier follow-up study of these children at 6 years of age (33% vs.
22%). The authors suggest that cognitive impairments may emerge as children grow older and continued monitoring, especially of behavioural and psychological problems, is needed beyond 10 years. Although prenatal diagnosis of isolated ACC is reliable, the authors caution there is a small risk that associated factors may be missed during prenatal screening.
Published Research currently on Corpal Website (from 2008)