Title: Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity
Authors: Paul, L.K., Brown, W.S, Adolphs, R., Tyszka, J.M., Richards, L.J., Mukherjee, P., Sherr, E.H.
Journal: Nature Reviews Neuroscience, 8, 287-299.
Published: 2007
This paper provides a comprehensive review of the research into ACC that has been done to date. The way the corpus callosum develops is described; this involves a complex series of multiple steps, where disruption at any stage can lead to ACC. A
review of genetic factors that cause ACC is provided along with possible environmental factors. The authors conclude that most cases of ACC do not have a known cause at this time. The wide-ranging consequence of ACC on behaviour and cognition is discussed. It is suggested that by grouping together individuals with similar brain anatomy we may be more successful at determining outcome. Individuals with primary ACC and good general cognitive ability often show a pattern of deficits in problem solving, social skills, processing emotion, and in the practical use of language and communication. These difficulties may be due to problems transferring information between hemispheres or to other abnormalities in the brain. Many neurodevelopmental and psychiatric conditions have been linked to corpus callosum malformation or malfunctioning, including schizophrenia, autism and attention deficit hyperactivity disorder. The study of ACC may therefore provide insight on how altered brain connectivity may contribute to these disorders, as well as how information is transferred in the typically developing brain.